![]() ![]() In order to resolve these issues, we propose a new hypothesis of “paralogous” stem-cell niches (PSNs) i.e., progressively altered parallel niches within an individual species throughout the life span of the organism. However, there is a lack of agreement in numerous fundamental areas, including origins of various BM stem-cell niches, cell identities, and their physiological roles in the BM. Currently, many studies in this field have relied on cell lineage tracing methods in mouse models, which have provided a significant advancement in our knowledge of skeletal and hematopoietic stem-cell niches in bone marrow (BM). Lineage commitment and differentiation of skeletal stem cells/bone marrow stromal cells (SSCs/BMSCs, often called bone marrow-derived “mesenchymal stem/stromal” cells) offer an important opportunity to study skeletal and hematopoietic diseases, and for tissue engineering and regenerative medicine.
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